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In children with congenital rubella infection the deficits remain stable; neurologic deterioration after the first years of life is not believed to occur. We have encountered three patients with a definite or presumed diagnosis of congenital rubella, in whom a progressive neurologic illness deveoped that began in the second decade and was characterized by spasticity, ataxia, intellectual deterioration, and seizures.High antibodiy titers to rubella virus in serum and spinal fluid were present in two, and all had increased cerebrospinal-fluid protein and gamma globulin. Extensive attemps to recover a virus from brain and body fluids were unsuccessful. The brains of two patients showed a widespread, progressive, subacute panencephalitis mainly affecting white matter. These data suggest that rubella virus may be a cause of progressive panencephalitis. |
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cerebrospinal fluid,elevated protein of
cerebrospinal fluid,gammaglobulin of
cerebrospinal fluid,oligoclonal IgG in
children
congenital infection,CNS
congenital infection,viral
encephalitis
encephalitis,viral
gait disorder
intellectual deterioration
intrauterine infection
intrauterine infection,viral
intrauterine infection,viral of CNS
neuropathology
pleocytosis of cerebrospinal fluid
progressive neurologic disorder
rubella encephalitis,progressive
rubella syndrome
rubella virus
serologic testing
serologic testing of cerebrospinal fluid
slow virus infection of CNS
viral infection
virus,slow
white matter disease
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